NYU Researchers Report Ability to Regrow Hair on Wounded Skin

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By stirring crosstalk among skin cells that form the roots of hair, researchers report they have regrown hair strands on damaged skin.

The findings better explain why hair does not normally grow on wounded skin, and may help in the search for better drugs to restore hair growth, say the study’s authors in a media release.

Led by researchers at NYU School of Medicine and published recently in the journal Nature Communications, the study examined the effect of distinct signaling pathways in damaged skin of laboratory mice. Experiments focused on cells called fibroblasts that secrete collagen, the structural protein most responsible for maintaining the shape and strength of skin and hair.

As part of their investigation, researchers activated the sonic hedgehog signaling pathway used by cells to communicate with each other. The pathway is known to be very active during the early stages of human growth in the womb, when hair follicles are formed, but is otherwise stalled in wounded skin in healthy adults. Researchers say this possibly explains why hair follicles fail to grow in skin replaced after injury or surgery, the release explains.

“Our results show that stimulating fibroblasts through the sonic hedgehog pathway can trigger hair growth not previously seen in wound healing,” says study senior investigator and cell biologist Mayumi Ito, PhD, an associate professor in the Ronald O. Perelman Department of Dermatology at NYU Langone Health.

Regrowing hair on damaged skin is an unmet need in medicine, Ito says, because of the disfigurement suffered by thousands from trauma, burns, and other injuries. However, her more immediate goal, she adds, is to signal mature skin to revert back to its embryonic state so that it can grow new hair follicles, not just on wounded skin, but also on people who have gone bald from aging.

Ito says scientists have until now assumed that, as part of the healing process, scarring and collagen buildup in damaged skin were behind its inability to regrow hair.

“Now we know that it’s a signaling issue in cells that are very active as we develop in the womb, but less so in mature skin cells as we age,” she adds in the release.

Key among the study’s findings was that no signs of hair growth were observed in untreated skin, but were observed in treated skin, offering evidence that sonic hedgehog signaling was behind the hair growth.

To bypass the risk of tumors reported in other experiments that turned on the sonic hedgehog pathway, the NYU Langone team turned on only fibroblasts located just beneath the skin’s surface where hair follicle roots (dermal papillae) first appear. Researchers also zeroed in on fibroblasts because the cells are known to help direct some of the biological processes involved in healing.

Hair regrowth was observed within 4 weeks after skin wounding in all treated mice, with hair root and shaft structures starting to appear after nine weeks.

Ito says her team plans further investigations into how chemical and genetic stimulants of fibroblasts might activate the sonic hedgehog pathway in wounded human skin. Her goal is to identify likely drug targets for hair regrowth, the release concludes.

[Source(s): NYU School of Medicine, PR Newswire]

NeoGraft Launches NeoGrafters App for Physician Partners

NeoGrafters

FUE hair restoration technology company NeoGraft announces the launch of NeoGrafters, a new on-demand hair transplant technician scheduling app for their physician partners.

The NeoGrafters app for physicians is now available on Google Play and the App Store and was designed to help simplify and streamline the technician scheduling process for partners offering NeoGraft follicular unit extraction (FUE) hair transplant services, according to a media release.

“On-demand services are becoming increasingly popular, so we looked for ways to improve our technician scheduling process for our physician partners,” says David Bays, vice president of business development for Venus Concept Ltd, the parent company for NeoGraft.

“Our new app will allow our NeoGraft physicians to create a booking request, choose their preferred technicians based on availability, review all estimated charges, and submit right from their phones. Once the procedures are completed, the physician can then review the final details, including graft counts, provide an in-app signature, and pay their balance via credit card,” Bays continues.

In addition to streamlining scheduling processes, NeoGraft has enhanced its technician and nurse recruitment and training programs, the release continues.

“Our recruiting process is very selective and on average, our hair transplant professionals have a minimum of 10 years of experience,” states Stephani Boyd, director of the NeoGrafters program.

“We closely monitor each member of our team to ensure high standards are being maintained and require all to successfully complete a yearly recertification review. Working under the direct supervision of the practice physician, our experienced NeoGrafters professionals are there to ensure patient safety is maintained and best possible procedure outcomes are achieved,” Boyd continues.

[Source(s): NeoGraft, PR Newswire]

4 Genetic Clues That You’ll Be Prone To Hair Loss

Genetic clues that you’ll be prone to hair loss are subject to a lot of myths that no one can seem to remember — is it your dad’s dad who’s hair pattern will somehow predict yours, or your mom’s dad? While knowing one way or the other won’t make a difference in the long run, there are a few gene variations and genetic disorders that can impact your chances of hair loss.

Genetics do appear to play an interesting role in the tendency to lose hair, and you can get clues to your genetic inheritance easier than ever before these days, thanks to things like home DNA testing kits. If these clues turn up in genetic testing, it’s worth seeing checking in with your dermatologist to see what they might mean for you.

How to Keep Your Hair Shiny, Voluminous, and Healthy For Life

Like your skin, your hair goes through an aging process. But rather than wrinkles, you’re left with dull, lifeless locks. Lots of things can impact your shine, volume, and color as you get older, like naturally drier skin, changes in your hair follicles, and even genetics—all of which can simply be out of your control.

The good news? Tweaking your hair routine, diet, and investing in top-notch products can bring your strands back to life.

Restoration Robotics to Hold Third Continuing Education Master Class for the ARTAS Robotic Hair Restoration System

Restoration Robotics Inc announces the third class in its continuing education Master Class Series for the ARTAS® Robotic Hair Restoration System. The Master Class Series trains physicians on best practices and the most up-to-date techniques for male aesthetic patients on our cutting-edge technology. The ARTAS® Hair Transplant System is the first and only robotic system in the world designed to aid surgeons in hair restoration procedures.

The Master Class will be led by Dr. Ken Anderson, MD, FISHRS, a double-board certified facial plastic and reconstructive surgeon who focused his practice to the specialty of hair restoration surgery since 2003.

Read the full article at www.nasdaq.com

5 Ways to Age-Proof Dull, Thinning Strands

Your hair quality changes decades before you start noticing grays, but the aging can be so subtle at first that you may not spot the damage until years later. In other words, when it comes to hair, it’s never too early for some serious maintenance.

There’s a growing body of research on how to keep hair in top shape—plus new hair-care options that go way beyond deep conditioner. Here, a look at some of the new products and not-so-obvious tricks to keep locks looking youthful.

Experimental Drug Reverses Skin Damage And Hair Loss

Scientists from Johns Hopkins successfully used the compound to reverse hair loss, hair whitening, and skin inflammation linked to diets high in fat and cholesterol in a series of mice experiments. The experimental D-threo-1-phenyl-2-decanoylmino-3-morpholino-1-propanol compound halts production of certain glycosphingolipids fats that are key components of skin and other cell membranes.